Selective Role for Mek1 but not Mek2 in the Induction of Epidermal NeoplasiaSCHOLL, Florence A; DUMESIC, Phillip A; BARRAGAN, Deborah I et al.Cancer research (Chicago, Ill.). 2009, Vol 69, Num 9, pp 3772-3778, issn 0008-5472, 7 p.Article

MEK1 and MEK2 isoforms regulate distinct functions in pancreatic cancer cellsLEI ZHOU; XIAODONG TAN; KAMOHARA, Hidenobu et al.Oncology reports. 2010, Vol 24, Num 1, pp 251-255, issn 1021-335X, 5 p.Article

Biological characterization of ARRY-142886 (AZD6244), a potent, highly selective mitogen-activated protein kinase kinase 1/2 inhibitorYEH, Tammie C; MARSH, Vivienne; MARLOW, Allison et al.Clinical cancer research. 2007, Vol 13, Num 5, pp 1576-1583, issn 1078-0432, 8 p.Article

Arabidopsis Mitogen-Activated Protein Kinase Kinases MKK1 and MKK2 Have Overlapping Functions in Defense Signaling Mediated by MEKK1, MPK4, and MKS1QIU, Jin-Long; LU ZHOU; YUN, Byung-Wook et al.Plant physiology (Bethesda). 2008, Vol 148, Num 1, pp 212-222, issn 0032-0889, 11 p.Article

Trametinib: First Global ApprovalWRIGHT, Cameron J. M; MCCORMACK, Paul L.Drugs (Basel). 2013, Vol 73, Num 11, pp 1245-1254, issn 0012-6667, 10 p.Article

A Raf-Like MAPKKK Gene DSM1 Mediates Drought Resistance through Reactive Oxygen Species Scavenging in RiceJING NING; XIANGHUA LI; HICKS, Leslie M et al.Plant physiology (Bethesda). 2010, Vol 152, Num 2, pp 876-890, issn 0032-0889, 15 p.Article

Characterization of a Novel Mitogen-Activated Protein Kinase Kinase 1/2 Inhibitor with a Unique Mechanism of Action for Cancer TherapyDAOUTI, Sherif; HUISHENG WANG; QING XIANG et al.Cancer research (Chicago, Ill.). 2009, Vol 69, Num 5, pp 1924-1932, issn 0008-5472, 9 p.Article

Phase I Pharmacokinetic and Pharmacodynamic Study of the Oral, Small-Molecule Mitogen-Activated Protein Kinase Kinase 1/2 Inhibitor AZD6244 (ARRY-142886) in Patients With Advanced CancersADJEI, Alex A; COHEN, Roger B; MALONEY, Lara et al.Journal of clinical oncology. 2008, Vol 26, Num 13, pp 2139-2146, issn 0732-183X, 8 p.Article

Characterization of CpSte11, a MAPKKK gene of Cryphonectria parasitica, and initial evidence of its involvement in the pheromone response pathwayPARK, Jin-Ah; KIM, Jung-Mi; PARK, Seung-Moon et al.Molecular plant pathology. 2012, Vol 13, Num 3, pp 240-250, issn 1464-6722, 11 p.Article

A phase I dose-finding, safety and tolerability study of AZD8330 in patients with advanced malignanciesCOHEN, Roger B; AAMDAL, Steinar; NYAKAS, Marta et al.European journal of cancer (1990). 2013, Vol 49, Num 7, pp 1521-1529, issn 0959-8049, 9 p.Article

ZmMKK3, a novel maize group B mitogen-activated protein kinase kinase gene, mediates osmotic stress and ABA signal responsesMAOYING ZHANG; JIAOWEN PAN; XIANGPEI KONG et al.Journal of plant physiology. 2012, Vol 169, Num 15, pp 1501-1510, issn 0176-1617, 10 p.Article

Suppression of MAPKAPK2 during mammalian hibernationABNOUS, Khalil; DIENI, Christopher A; STOREY, Kenneth B et al.Cryobiology (Print). 2012, Vol 65, Num 3, pp 235-241, issn 0011-2240, 7 p.Article

Brassinosteroid regulates stomatal development by GSK3-mediated inhibition of a MAPK pathwayKIM, Tae-Wuk; MICHNIEWICZ, Marta; BERGMANN, Dominique C et al.Nature (London). 2012, Vol 482, Num 7385, pp 419-422, issn 0028-0836, 4 p.Article

Design and synthesis fo orally available MEK inhibitors with potent in vivo antitumor efficacyADAMS, Mark E; WALLACE, Michael B; KANOUNI, Toufike et al.Bioorganic & medicinal chemistry letters (Print). 2012, Vol 22, Num 7, pp 2411-2414, issn 0960-894X, 4 p.Article

Cotton GhMKK5 affects disease resistance, induces HR-like cell death, and reduces the tolerance to salt and drought stress in transgenic Nicotiana benthamianaLIANG ZHANG; YUZHEN LI; WENJING LU et al.Journal of experimental botany. 2012, Vol 63, Num 10, pp 3935-3951, issn 0022-0957, 17 p.Article

Two mitogen-activated protein kinase kinases, MKK1 and MEK2, are involved in wounding- and specialist lepidopteran herbivore Manduca sexta-induced responses in Nicotiana attenuataHEINRICH, Maria; BALDWIN, Ian T; JIANQIANG WU et al.Journal of experimental botany. 2011, Vol 62, Num 12, pp 4355-4365, issn 0022-0957, 11 p.Article

Design and biological evaluation of imidazo[1,2-a]pyridines as novel and potent ASK1 inhibitorsTERAO, Yoshito; SUZUKI, Hideo; SHUHEI YAO et al.Bioorganic & medicinal chemistry letters (Print). 2012, Vol 22, Num 24, pp 7326-7329, issn 0960-894X, 4 p.Article

Proteome profiling of immortalization-to-senescence transition of human breast epithelial cells identified MAP2K3 as a senescence-promoting protein which is downregulated in human breast cancerMIN JIA; SOUCHELNYTSKYI, Nazariy; HELLMAN, Ulf et al.Proteomics. Clinical applications (Print). 2010, Vol 4, Num 10-11, pp 816-828, issn 1862-8346, 13 p.Article

Résultats et perspectives des thérapies ciblées : Oncodermatologie = Targeted therapies in advanced melanomaPAGES, C; LEBBE, C.La Lettre du cancérologue (Boulogne). 2011, Vol 20, Num 9, pp 572-574, issn 1165-113X, 3 p.Article

Mélanome = MelanomaMORTIER, L.La Lettre du cancérologue (Boulogne). 2013, Vol 22, Num 7, issn 1165-113X, 315-323 [8 p.]Article

ZmMKK4, a novel group C mitogen-activated protein kinase kinase in maize (Zea mays), confers salt and cold tolerance in transgenic ArabidopsisXIANGPEI KONG; JIAOWEN PAN; MAOYING ZHANG et al.Plant, cell and environment (Print). 2011, Vol 34, Num 8, pp 1291-1303, issn 0140-7791, 13 p.Article

Effect of SMURF2Targeting on Susceptibility to MEK Inhibitors in MelanomaSMITH, Michael P; FERGUSON, Jennifer; AROZARENA, Imanol et al.Journal of the National Cancer Institute. 2013, Vol 105, Num 1, pp 33-46, issn 0027-8874, 14 p.Article

Phase II Study of the MEK1/MEK2 Inhibitor Trametinib in Patients With Metastatic BRAF-Mutant Cutaneous Melanoma Previously Treated With or Without a BRAF InhibitorKIM, Kevin B; KEFFORD, Richard; GONZALEZ, Rene et al.Journal of clinical oncology. 2013, Vol 31, Num 4, pp 482-489, issn 0732-183X, 8 p.Article

The role of MAP kinases and MAP kinase phosphatase-1 in resistance to breast cancer treatmentHAAGENSON, Kelly K; GEN SHENG WU.Cancer metastasis reviews. 2010, Vol 29, Num 1, pp 143-149, issn 0167-7659, 7 p.Article

Selective Growth Inhibition in BEAT Mutant Thyroid Cancer by the Mitogen-Activated Protein Kinase Kinase 1/2 Inhibitor AZD6244BALL, Douglas W; NING JIN; ROSEN, D. Marc et al.The Journal of clinical endocrinology and metabolism. 2007, Vol 92, Num 12, pp 4712-4718, issn 0021-972X, 7 p.Article